ProntoSIL C8 ace-EPS

The ProntoSIL C8 ace-EPS belongs to the new group of stationary RP-supports with polar embedded groups. The packing is very stable over a wide pH range (pH 1-10). In comparison to the corresponding C18 packing the ProntoSIL C8 ace-EPS shows even a higher polar selectivity. Due to the shorter alkyl chain the influence of the polar group in the contribution to the retention mechanism of the stationary phase is increased. The silanophilic activity of the support is very low. Ultra strong basic compounds with pka values higher than 9 (like amitriptyline) can be eluted from the column in neutral pH values with excellent symmetrical peak shapes. The main application area of these packings is in the pharmaceutical industry where the analytes often have basic or acidic groups. For the separation of these compounds these supports are showing an enhanced polar selectivity.